Edward Charles Dodds (1899-1973)

Edward Charles Dodds [3] researched the function and effects of natural and artificial hormones [4] on the endocrine system in England during the twentieth century. Though he first worked with hormones [4] such as insulin, Dodds focused on the effects of estrogen [5] in the body and how to replicate those effects with artificial substances. In 1938, along with chemist Robert Robinson, Dodds synthesized the first synthetic estrogen [6] called diethylstilbestrol. Despite the wide use of diethylstilbestrol to treat a variety of hormonal problems like miscarriages during pregnancy [7] and menopause, Dodds argued against the use of synthetic substances in the human body due to their unknown effects. Just before Dodds's death, his hypotheses were confirmed when researchers showed that people exposed to diethylstilbestrol often developed cancer. Dodds was one of the first researchers to investigate the endocrine or hormone [8] system in humans [9], and his research led to the creation of other synthetic hormones [4] used in contraceptive pills and hormone [8] replacements.